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Article

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition.

Cancer letters - 28 May 2026

Hu Chuling, Cai Du, You Weiqiang, Zhou Zhengran, Liu Junwei, Li Cheng-Hang, Lv Min-Yi, Gai Bao-Wen, Chen Chong, Huang Xinxin, Wang Run Xian, Wu Xiao-Jian, Hu Peishan, Gao Feng

Abstract excerpt

The heterogeneity of tumor immune microenvironment accounts for differential prognosis and immunotherapy responsiveness among colorectal cancer (CRC) patients. Here, we developed a novel immune classification for colorectal cancer through integrative multi-omics analysis. Immune-related gene expression, mutation, and methylation profiles were collected from two large-scale multi-omics CRC cohort (TCGA, n = 627;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41819525
DOI: 10.1016/j.canlet.2026.218425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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