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Integrating tumor mutational burden and transcriptome expression into prediction of immune checkpoint inhibitor response and prognosis of patients with colon cancer.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Apr 2022

Liang L, Jiang W, Zheng Y, Liu T S, Shen X Z, Chen Y J

Abstract excerpt

Whether tumor mutational burden (TMB), which refers to the total number of somatic or acquired mutations per million bases in a particular region of the tumor genome, can serve as a predictive biomarker of immune checkpoint inhibitor (ICI) therapy for colon cancer remains unclear. Hereby, we retrospectively investigated the differentially expressed genes (DEGs) based on the level of TMB and tried to established a...

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Biomarkers, Tumor
Colonic Neoplasms
Immune Checkpoint Inhibitors
Mutation
Prognosis

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PMID: 35988929
DOI: 10.26402/jpp.2022.2.04

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