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Article

Two immune-enhanced molecular subtypes differ in inflammation, immune checkpoints, mutations, and prognostic outcome in stage I-II colonic carcinoma.

Journal of biochemical and molecular toxicology - 1 Apr 2021

Tang Dongxin, Huang Wei, Yang Zhu, Wu Xin, Sang Xianan, Wang Kuilong, Cao Gang, Hao Min

Abstract excerpt

The purpose of this paper is to investigate the immune function of the tumor microenvironment and its clinical correlation with colonic carcinoma. Immune genes were downloaded from the The Cancer Genome Atlas database. Five subtypes are obtained by cluster screening based on immune gene expression data. The C3 and C4 subtypes show stronger immune activity. In addition, the C4 subtype has the largest number of...

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PMID: 33410236
DOI: 10.1002/jbt.22703

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