Article
Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.
Biomolecules - 22 Sept 2020
Kahoul Yasmina, Oger Frédérik, Montaigne Jessica, Froguel Philippe, Breton Christophe, Annicotte Jean-Sébastien
Abstract excerpt
Besides its role as a cell cycle and proliferation regulator, the INK4a/ARF (CDKN2A) locus and its associated pathways are thought to play additional functions in the control of energy homeostasis. Genome-wide association studies in humans and rodents have revealed that single nucleotide polymorphisms in this locus are risk factors for obesity and related metabolic diseases including cardiovascular complications...
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