Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR inhibits TRC8‐mediated HMOX1 ubiquitination and regulates ferroptosis in ovarian cancer

1 Sept 2022

Abstract excerpt

Dear Editor, The study is the first to confirm that methylenetetrahydrofolate reductase (MTHFR) could inhibit HMOX1 ubiquitination degradation by competitive interaction with TRC8, followed by blocking the occurrence of ferroptosis in ovarian cancer (OV) cells, and promote the tumour cells growth. OV attributes to the world's second most familiar cause of gynaecologic cancer death.1 Recent research studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36149747
DOI: 10.1002/ctm2.1013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR inhibits TRC8‐mediated HMOX1 ubiquitination and regulates ferroptosis in ovarian cancerPMID 36149747Read ↗

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expressionSemantic proximity Read ↗

Association between MTHFR gene polymorphism and the risk of ovarian cancer: a meta-analysis of the literature.Semantic proximity Read ↗

Up-Regulation of MTHFD2 is Associated With Clinicopathological Characteistics and Poor Survival in Ovarian Cancer, Possibly By Regulating MOB1A SignalingSemantic proximity Read ↗

The association between MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis of 18,628 individuals.Semantic proximity Read ↗

LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by promoting DNMT1-mediated CDO1 promoter hypermethylationSemantic proximity Read ↗

Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers in ovarian cancer risk.Semantic proximity Read ↗

DHFR silencing effects on biological behaviour of ovarian carcinoma cells in vitroSemantic proximity Read ↗

Mutant p53 <sup>R175H</sup> -Associated Protection of Ovarian Cancer Precursor Cells from Cisplatin Requires Expression of SLC6A6 Taurine TransporterSemantic proximity Read ↗

Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.Semantic proximity Read ↗

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma modelSemantic proximity Read ↗

Melatonin reduces cell motility and antioxidant defenses in ovarian cancer cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.