The association between MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis of 18,628 individuals.

doi:10.1007/s11033-012-1970-8

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Article

The association between MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis of 18,628 individuals.

Molecular biology reports - 1 Mar 2013

Ma Chengbin, Liu Yan, Zhang Wenying, Liu Ping

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR polymorphisms have been suggested to be associated with risk of various cancers. MTHFR C677T polymorphism is a common genetic alteration and may affect the host susceptibility to ovarian cancer. The aim of this study was to investigate the association between MTHFR C677T polymorphism and ovarian cancer risk...

Topics

Alleles
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Odds Ratio
Ovarian Neoplasms
Polymorphism, Single Nucleotide
Risk

Source

Open in PubMed

Identifiers

PMID: 23329275
DOI: 10.1007/s11033-012-1970-8

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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