Association between MTHFR gene polymorphism and the risk of ovarian cancer: a meta-analysis of the literature.

doi:10.2174/13816128113199990564

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Article

Association between MTHFR gene polymorphism and the risk of ovarian cancer: a meta-analysis of the literature.

Current pharmaceutical design - 1 Jan 2014

Pu Danhua, Jiang Shi-Wen, Wu Jie

Abstract excerpt

OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for DNA biosynthesis and the epigenetic process of DNA methylation. MTHFR gene polymorphisms have been implicated as risk factors for several types of cancers. However, reports on the association of MTHFR polymorphisms with ovarian cancers are inconclusive. The aim of this study is to summarize on the reported data and...

Topics

Asian People
Female
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Ovarian Neoplasms
Polymorphism, Genetic
Risk Factors
White People

Source

Open in PubMed

Identifiers

PMID: 24720627
DOI: 10.2174/13816128113199990564

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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