Article
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics.
Viruses - 12 Sept 2022
Veleanu Andrei, Kelch Maximilian A, Ye Chengjin, Flohr Melanie, Wilhelm Alexander, Widera Marek, Martinez-Sobrido Luis, Ciesek Sandra, Toptan Tuna
Abstract excerpt
Some of the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are less susceptible to neutralization with post-vaccine sera and monoclonal antibodies targeting the viral spike glycoprotein. This raises concerns of disease control, transmissibility, and severity. Numerous substitutions have been identified to increase viral fitness within the nucleocapsid and nonstructural proteins, in...
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