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Article

Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2.

Cellular & molecular immunology - 1 Nov 2022

Peng Qiaoli, Zhou Runhong, Liu Na, Wang Hui, Xu Haoran, Zhao Meiqing, Yang Dawei, Au Ka-Kit, Huang Haode, Liu Li, Chen Zhiwei

Abstract excerpt

Mutations in SARS-CoV-2 variants of concern (VOCs) have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies (NAbs). How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be investigated. The entry efficiency of individual spike mutations was determined in vitro using pseudotyped viruses. BALB/c mice were immunized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36224497
DOI: 10.1038/s41423-022-00924-8
PMCID: PMC9554397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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