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Article

Single spike mutation differentiating XBB.1 and XBB.1.5 enhances SARS-CoV-2 cell-to-cell transmission and facilitates serum-mediated enhancement.

Frontiers in immunology - 1 Jan 2024

Criscuolo Elena, Giuliani Benedetta, Castelli Matteo, Cavallaro Mattia, Sisti Sofia, Burioni Roberto, Ferrari Davide, Mancini Nicasio, Locatelli Massimo, Clementi Nicola

Abstract excerpt

Introduction: The ongoing emergence of SARS-CoV-2 variants poses significant challenges to existing therapeutics. The spike (S) glycoprotein is central to both viral entry and cell-to-cell transmission via syncytia formation, a process that confers resistance to neutralizing antibodies. The mechanisms underlying this resistance, particularly in relation to spike-mediated fusion, remain poorly understood. Methods:...

Topics

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Antibodies, Neutralizing
Antibodies, Viral
Cell Fusion
Chlorocebus aethiops
Giant Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

Virus Internalization

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Identifiers

PMID: 39664381
DOI: 10.3389/fimmu.2024.1501200
PMCID: PMC11631925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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