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Article

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.

Cell host & microbe - 14 Apr 2021

Shen Xiaoying, Tang Haili, McDanal Charlene, Wagh Kshitij, Fischer William, Theiler James, Yoon Hyejin, Li Dapeng, Haynes Barton F, Sanders Kevin O, Gnanakaran Sandrasegaram, Hengartner Nick, Pajon Rolando, Smith Gale, Glenn Gregory M, Korber Bette, Montefiori David C

Abstract excerpt

All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of generating protective neutralizing antibodies. The recent emergence and rapid spread of several SARS-CoV-2 variants carrying multiple spike mutations raise concerns about possible immune escape. One variant, first identified in the United Kingdom (B.1.1.7, also called 20I/501Y.V1), contains eight spike mutations with potential...

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Aged, 80 and over
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

COVID-19 Vaccines

Neutralization Tests

Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 33705729
DOI: 10.1016/j.chom.2021.03.002
PMCID: PMC7934674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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