Article
Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System.
International journal of molecular sciences - 2 May 2023
Cordsmeier Arne, Jungnickl Doris, Herrmann Alexandra, Korn Klaus, Ensser Armin
Abstract excerpt
SARS-CoV-2, the causative agent of COVID-19, has spread around the world with more than 700 million cases and 6.8 million deaths. Various variants of concern (VoC) have emerged due to mutations and recombination and concurrent selection for increased viral fitness and immune evasion. The viral protein that primarily determines the pathogenicity, infectivity, and transmissibility is the Spike protein. To analyze...
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