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Exploring the impact of CYP11A1's missense SNPs on the interaction between CYP11A1 and cholesterol: A comprehensive structural analysis and MD simulation study.

Computational biology and chemistry - 1 Oct 2023

Redouane Salaheddine, Harmak Houda, Elkarhat Zouhair, Charoute Hicham, Malki Abderrahim, Barakat Abdelhamid, Rouba Hassan

Abstract excerpt

The process of steroidogenesis plays a vital role in human physiology as it governs the biosynthesis of mineralocorticoids, glucocorticoids, and androgens. These three classes of steroid hormones are primarily produced in the adrenal and gonadal glands through steroidogenesis pathways. Initiated by the side chain cleavage of cholesterol (CLR), this process leads to the conversion of cholesterol into pregnenolone...

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PMID: 37552904
DOI: 10.1016/j.compbiolchem.2023.107937

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