Article
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nature communications - 9 Feb 2018
Werner-Klein Melanie, Scheitler Sebastian, Hoffmann Martin, Hodak Isabelle, Dietz Klaus, Lehnert Petra, Naimer Veronika, Polzer Bernhard, Treitschke Steffi, Werno Christian, Markiewicz Aleksandra, Weidele Kathrin, Czyz Zbigniew, Hohenleutner Ulrich, Hafner Christian, Haferkamp Sebastian, Berneburg Mark, Rümmele Petra, Ulmer Anja, Klein Christoph A
Abstract excerpt
Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined the time point of metastatic seeding relative to tumour thickness and genomic alterations in melanoma. Here, we find that lymphatic dissemination occurs shortly after dermal invasion of the primary lesion at a median thickness of ~0.5 mm and that typical driver...
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