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Article

USP8, USP48, BRAF and TP53 mutations in crooke cell adenoma.

Pituitary - 5 Oct 2025

Kober Paulina, Szczepaniak Magdalena, Pękul Monika, Rusetska Natalia, Mossakowska Beata J, Kowalik Artur, Maksymowicz Maria, Zieliński Grzegorz, Kunicki Jacek, Bujko Mateusz

Abstract excerpt

PURPOSE: Crooke cell adenomas (CCAs) are rare histological subtype of corticotroph pituitary adenomas (cPAs) commonly related to worse prognosis in patients. Notable progress in understanding of the molecular background of cPAs has been made recently but biology of CCAs remains poorly recognized. Results of our previous study suggested distinct frequency of the known recurrent mutations in CCAs than in sparsely...

Read the complete abstract on PubMed

Topics

Humans
Tumor Suppressor Protein p53
Ubiquitin Thiolesterase
Female
Proto-Oncogene Proteins B-raf
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Adult

Mutation

Endosomal Sorting Complexes Required for Transport

Endopeptidases

Aged

Retrospective Studies

Adenoma

Pituitary Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41047423
DOI: 10.1007/s11102-025-01566-5
PMCID: PMC12497664

Genes

TP53
USP8
BRAF
USP48

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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USP8, USP48, BRAF and TP53 mutations in crooke cell adenoma.PMID 41047423Read ↗

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