Article

Transfer learning identifies sequence determinants of regulatory element accessibility

2022-08-05

Abstract excerpt

Dysfunction of regulatory elements through genetic variants is a central mechanism in the pathogenesis of disease. To better understand disease etiology, there is consequently a need to understand how DNA encodes regulatory activity. Deep learning methods show great promise for modeling of biomolecular data from DNA sequence but are limited to large input data for training. Here, we develop ChromTransfer, a transf...

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Literature Corpus work: 3bc988d6-2da2-586d-b4a8-98d9d558254d
DOI: 10.1101/2022.08.05.502903

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