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Structural, molecular, and functional insights into Schlafen proteins

29 Jun 2022

Abstract excerpt

Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high sequence homology. However, each SLFN is functionally divergent and differentially expressed in various tissues and species, showing a wide range of expression in cancer and normal cells. SLFNs are involved in various cellular and tissue-specific processes, including DNA replication, proliferation, immune and interferon...

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PMID: 35768579
DOI: 10.1038/s12276-022-00794-0

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