Article

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations

2026-02-04

Abstract excerpt

Schlafens (SLFNs) are interferon-inducible regulators of RNA metabolism and cell fate. SLFN14 is a ribosome-associated endoribonuclease whose pathogenic variants cause autosomal dominant inherited thrombocytopenia (IT), but the underlying disease mechanism has been unclear. We show that SLFN14 represses global protein synthesis through selective cleavage of type II tRNAs. IT-linked mutations alter RNA substrate sp...

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Literature Corpus work: d1ed6425-f372-5715-95f3-5d13af990ab6
DOI: 10.64898/2026.02.03.703619

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