Article

Cryo-EM structures of SAMD9L reveal the arrangement and coordination of multi-domains

2026-02-02

Abstract excerpt

Human sterile alpha motif domain-containing 9 (hSAMD9L) is a large (∼185 kDa) multi-domain interferon-stimulated antiviral effector with strong translation-inhibitory activity. Inherited heterozygous gain-of-function (GoF) mutations in SAMD9L directly associated with severe bone marrow failure syndromes. Using single-particle cryo-electron microscopy (cryo-EM), we determined the first structures of both full-lengt...

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Literature Corpus work: 5d44ddcf-b9d4-51b3-a96e-6e1c77bd69bb
DOI: 10.64898/2026.02.01.703102

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