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Article

Schlafen 11 Restricts Flavivirus Replication

23 May 2019

Abstract excerpt

We provide evidence that the cellular protein Schlafen 11 (Slfn11) impairs replication of flaviviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV). However, replication of single-stranded negative RNA viruses was not affected. Specifically, Slfn11 decreases the infectivity of WNV potentially by preventing virus-induced modifications of the host tRNA repertoire that could lead to...

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Identifiers

PMID: 31118262
DOI: 10.1128/jvi.00104-19

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