Article
BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
Cell cycle (Georgetown, Tex.) - 1 Dec 2012
Martinez-Outschoorn Ubaldo E, Balliet Renee, Lin Zhao, Whitaker-Menezes Diana, Birbe Ruth C, Bombonati Alessandro, Pavlides Stephanos, Lamb Rebecca, Sneddon Sharon, Howell Anthony, Sotgia Federica, Lisanti Michael P
Abstract excerpt
Mutations in the BRCA1 tumor suppressor gene are commonly found in hereditary breast cancer. Similarly, downregulation of BRCA1 protein expression is observed in the majority of basal-like breast cancers. Here, we set out to study the effects of BRCA1 mutations on oxidative stress in the tumor microenvironment. To mimic the breast tumor microenvironment, we utilized an in vitro co-culture model of human...
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