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Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function

31 Mar 2021

Abstract excerpt

High levels of the anti-apoptotic BCL-2 family member MCL-1 are frequently found in breast cancer and, appropriately, BH3-mimetic drugs that specifically target MCL-1's function in apoptosis are in development as anti-cancer therapy. MCL-1 also has reported non-canonical roles that may be relevant in its tumour-promoting effect. Here we investigate the role of MCL-1 in clinically relevant breast cancer models and...

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PMID: 33785871
DOI: 10.1038/s41418-021-00773-4

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