Article
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.
Cell cycle (Georgetown, Tex.) - 15 Jun 2010
Martinez-Outschoorn Ubaldo E, Pavlides Stephanos, Whitaker-Menezes Diana, Daumer Kristin M, Milliman Janet N, Chiavarina Barbara, Migneco Gemma, Witkiewicz Agnieszka K, Martinez-Cantarin Maria P, Flomenberg Neal, Howell Anthony, Pestell Richard G, Lisanti Michael P, Sotgia Federica
Abstract excerpt
Loss of stromal caveolin 1 (Cav-1) is a novel biomarker for cancer-associated fibroblasts that predicts poor clinical outcome in breast cancer and DCIS patients. We hypothesized that epithelial cancer cells may have the ability to drive Cav-1 downregulation in adjacent normal fibroblasts, thereby promoting the cancer associated fibroblast phenotype. To test this hypothesis directly, here we developed a novel...
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