Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites

14 Sept 2022

Abstract excerpt

Efforts to control the global malaria health crisis are undermined by antimalarial resistance. Identifying mechanisms of resistance will uncover the underlying biology of the Plasmodium falciparum malaria parasites that allow evasion of our most promising therapeutics and may reveal new drug targets. We utilized fosmidomycin (FSM) as a chemical inhibitor of plastidial isoprenoid biosynthesis through the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aquaculture disease management and microbiota
Share to Genomics and Phylogenetic Studies
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36103572
DOI: 10.1371/journal.ppat.1010803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasitesPMID 36103572Read ↗

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.Semantic proximity Read ↗

Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from FosmidomycinSemantic proximity Read ↗

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparumSemantic proximity Read ↗

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapiesSemantic proximity Read ↗

Novel <i>Plasmodium falciparum</i> metabolic network reconstruction identifies shifts associated with clinical antimalarial resistanceSemantic proximity Read ↗

Targeting host glycolysis as a strategy for antimalarial developmentSemantic proximity Read ↗

Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum.Semantic proximity Read ↗

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.Semantic proximity Read ↗

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Semantic proximity Read ↗

Real-time measurements of ATP dynamics via ATeams in <i>Plasmodium falciparum</i> reveal drug-class-specific response patternsSemantic proximity Read ↗

Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.