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Article

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.

mBio - 8 Dec 2020

Fisher Gillian M, Cobbold Simon A, Jezewski Andrew, Carpenter Emma F, Arnold Megan, Cowell Annie N, Tjhin Erick T, Saliba Kevin J, Skinner-Adams Tina S, Lee Marcus C S, Odom John Audrey, Winzeler Elizabeth A, McConville Malcolm J, Poulsen Sally-Ann, Andrews Katherine T

Abstract excerpt

Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associated with in vitro resistance to a primary sulfonamide glycoside (PS-3). Flux through the upper glycolysis pathway was...

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Identifiers

PMID: 33293381
DOI: 10.1128/mBio.02842-20
PMCID: PMC7733947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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