Article

Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa

2023-10-12

Abstract excerpt

<title>Abstract</title> <p>Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates, yet the genetic basis of CaP in African men has been understudied. We used genomic data from 3,963 CaP cases and 3,509 controls recruited in Ghana, Nigeria, Senegal, South Africa, and Uganda, to infer ancestry-specific genetic architectures and fine-mapped disease associations. Fifteen independe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e790d59-e647-5454-917c-cbe562b561eb
DOI: 10.21203/rs.3.rs-3378303/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan AfricaDOI 10.21203/rs.3.rs-3378303/v1Read

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.Semantic proximity Read

A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in AfricaSemantic proximity Read

A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa.Semantic proximity Read

Prostate cancer genetic risk and associated aggressive disease in men of African ancestrySemantic proximity Read

Review of prostate cancer genomic studies in AfricaSemantic proximity Read

Genetic Hitchhiking and Population Bottlenecks Contribute to Prostate Cancer Disparities in Men of African Descent.Semantic proximity Read

African-specific molecular taxonomy of prostate cancer.Semantic proximity Read

Genetic risk of prostate cancer in Ugandan men.Semantic proximity Read

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.Semantic proximity Read

African-specific prostate cancer molecular taxonomySemantic proximity Read

Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.Semantic proximity Read

Generalizability of established prostate cancer risk variants in men of African ancestry.Semantic proximity Read