Article
Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.
Nature genetics - 1 Oct 2024
Janivara Rohini, Chen Wenlong C, Hazra Ujani, Baichoo Shakuntala, Agalliu Ilir, Kachambwa Paidamoyo, Simonti Corrine N, Brown Lyda M, Tambe Saanika P, Kim Michelle S, Harlemon Maxine, Jalloh Mohamed, Muzondiwa Dillon, Naidoo Daphne, Ajayi Olabode O, Snyper Nana Yaa, Niang Lamine, Diop Halimatou, Ndoye Medina, Mensah James E, Abrahams Afua O D, Biritwum Richard, Adjei Andrew A, Adebiyi Akindele O, Shittu Olayiwola, Ogunbiyi Olufemi, Adebayo Sikiru, Nwegbu Maxwell M, Ajibola Hafees O, Oluwole Olabode P, Jamda Mustapha A, Pentz Audrey, Haiman Christopher A, Spies Petrus V, van der Merwe André, Cook Michael B, Chanock Stephen J, Berndt Sonja I, Watya Stephen, Lubwama Alexander, Muchengeti Mazvita, Doherty Sean, Smyth Natalie, Lounsbury David, Fortier Brian, Rohan Thomas E, Jacobson Judith S, Neugut Alfred I, Hsing Ann W, Gusev Alexander, Aisuodionoe-Shadrach Oseremen I, Joffe Maureen, Adusei Ben, Gueye Serigne M, Fernandez Pedro W, McBride Jo, Andrews Caroline, Petersen Lindsay N, Lachance Joseph, Rebbeck Timothy R
Abstract excerpt
Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genetic basis of prostate cancer in African men has been understudied. We used genomic data from 3,963 cases and 3,509 controls from Ghana, Nigeria, Senegal, South Africa and Uganda to infer ancestry-specific genetic architectures and fine-map disease associations. Fifteen independent associations at 8q24.21, 6q22.1 and...
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