Article
Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells.
Toxicology and applied pharmacology - 1 Nov 2022
Okamura Kazuyuki, Sato Miyuki, Suzuki Takehiro, Nohara Keiko
Abstract excerpt
Exposure to inorganic arsenic has been known to induce cancers in various organs, however, the underlying mechanisms remain unclear. Premature senescence refers to the irreversible growth arrest induced by stress stimuli. The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development. In this study, we examined whether arsenite exposure causes...
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