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Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids

22 Mar 2021

Abstract excerpt

Abstract Background Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exosomes have shown anti-senescence effects in various diseases. We applied novel organoid culture technology to establish and characterize cholangiocyte organoids (cholangioids) with...

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PMID: 33752720
DOI: 10.1186/s13287-021-02271-3

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