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Article

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

PLoS biology - 2 Dec 2008

Coppé Jean-Philippe, Patil Christopher K, Rodier Francis, Sun Yu, Muñoz Denise P, Goldstein Joshua, Nelson Peter S, Desprez Pierre-Yves, Campisi Judith

Abstract excerpt

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secreted by senescent cells. We show that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy. This...

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Identifiers

PMID: 19053174
DOI: 10.1371/journal.pbio.0060301
PMCID: PMC2592359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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