Article
Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype.
Hepatology (Baltimore, Md.) - 1 Mar 2003
Schnabl Bernd, Purbeck Carrie A, Choi Youkyung Hwang, Hagedorn Curt H, Brenner David
Abstract excerpt
Limited proliferative capacity is a characteristic of most normal human cells and results in a growth-arrested state, called replicative senescence. Functional expression of the telomerase catalytic subunit (human telomerase reverse transcriptase; hTERT) in human activated hepatic stellate cells (HSCs) rescues them from death with immortalization and maintains an activated HSC phenotype. The aim of this study was...
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