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Article

Correlation of Matrisome-Associatted Gene Expressions with LOX Family Members in Astrocytomas Stratified by IDH Mutation Status.

International journal of molecular sciences - 23 Aug 2022

Laurentino Talita de Sousa, Soares Roseli da Silva, Marie Suely Kazue Nagahashi, Oba-Shinjo Sueli Mieko

Abstract excerpt

Tumor cell infiltrative ability into surrounding brain tissue is a characteristic of diffusely infiltrative astrocytoma and is strongly associated with extracellular matrix (ECM) stiffness. Collagens are the most abundant ECM scaffolding proteins and contribute to matrix organization and stiffness. LOX family members, copper-dependent amine oxidases, participate in the collagen and elastin crosslinking that...

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Identifiers

PMID: 36076905
DOI: 10.3390/ijms23179507
PMCID: PMC9455728

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