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Article

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas.

Neuro-oncology - 9 Oct 2018

Zhang Lei, He Liqun, Lugano Roberta, Roodakker Kenney, Bergqvist Michael, Smits Anja, Dimberg Anna

Abstract excerpt

Background: Vascular gene expression patterns in lower-grade gliomas (LGGs; diffuse World Health Organization [WHO] grades II-III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH) mutation status affects vascular phenotype. Methods: Gene expression was analyzed using an in-house dataset derived...

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Source

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Identifiers

PMID: 29846705
DOI: 10.1093/neuonc/noy088
PMCID: PMC6176806

Genes

ANGPT2
LAMA4
SERPINH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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