Article
Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting.
International journal of molecular sciences - 21 Jul 2023
Radić Jelena, Kožik Bojana, Nikolić Ivan, Kolarov-Bjelobrk Ivana, Vasiljević Tijana, Vranjković Bojana, Despotović Sanja
Abstract excerpt
LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development. We performed a review of the current knowledge on the roles...
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