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Article

High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas.

Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2022

Luo Chun-Hua, Shi Yu, Liu Yu-Qi, Liu Qing, Mao Min, Luo Min, Yang Kai-Di, Wang Wen-Ying, Chen Cong, Niu Qin, Yan Ze-Xuan, Miao Jing-Ya, Zhang Xiao-Ning, Zeng Hui, Li Lei, Bian Xiu-Wu, Ping Yi-Fang

Abstract excerpt

Glioma progression is accompanied with increased tumor tissue stiffness, yet the underlying mechanisms are unclear. Herein, we employed atomic force microscopy analysis to show that tissue stiffness was higher in isocitrate dehydrogenase (IDH)-wild type gliomas than IDH-mutant gliomas. Bioinformatic analyses revealed that tissue inhibitor of metalloproteinase-1 (TIMP1) was one of the preferentially upregulated...

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Identifiers

PMID: 35882906
DOI: 10.1038/s41374-022-00825-4

Genes

TIMP1
IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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