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Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer

21 Dec 2020

Abstract excerpt

The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remodeling plays a key role in the angiogenesis surrounding tumors, whereby a corrupt tumor microenvironment (TME) takes...

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PMID: 33371259
DOI: 10.3390/ijms21249751

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