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Article

Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.

Nature genetics - 1 Sept 2022

Baca Sylvan C, Singler Cassandra, Zacharia Soumya, Seo Ji-Heui, Morova Tunc, Hach Faraz, Ding Yi, Schwarz Tommer, Huang Chia-Chi Flora, Anderson Jacob, Fay André P, Kalita Cynthia, Groha Stefan, Pomerantz Mark M, Wang Victoria, Linder Simon, Sweeney Christopher J, Zwart Wilbert, Lack Nathan A, Pasaniuc Bogdan, Takeda David Y, Gusev Alexander, Freedman Matthew L

Abstract excerpt

Many genetic variants affect disease risk by altering context-dependent gene regulation. Such variants are difficult to study mechanistically using current methods that link genetic variation to steady-state gene expression levels, such as expression quantitative trait loci (eQTLs). To address this challenge, we developed the cistrome-wide association study (CWAS), a framework for identifying genotypic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 36071171
DOI: 10.1038/s41588-022-01168-y
PMCID: PMC9784646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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