Article
Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children.
PLoS genetics - 1 Sept 2022
Li Shaobo, Chiang Charleston W K, Myint Swe Swe, Arroyo Katti, Chan Tsz Fung, Morimoto Libby, Metayer Catherine, de Smith Adam J, Walsh Kyle M, Wiemels Joseph L
Abstract excerpt
BACKGROUND: Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. PA has at least a 50% higher incidence in populations of European ancestry compared to other ancestral groups, which may be due in part to genetic differences. METHODS: We first compared the global proportions of European, African, and Amerindian ancestries in 301 PA cases and 1185 controls of self-identified Latino ethnicity from...
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