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Article

Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas.

Human molecular genetics - 15 Apr 2012

Fejerman Laura, Chen Gary K, Eng Celeste, Huntsman Scott, Hu Donglei, Williams Amy, Pasaniuc Bogdan, John Esther M, Via Marc, Gignoux Christopher, Ingles Sue, Monroe Kristine R, Kolonel Laurence N, Torres-Mejía Gabriela, Pérez-Stable Eliseo J, Burchard Esteban González, Henderson Brian E, Haiman Christopher A, Ziv Elad

Abstract excerpt

Among US Latinas and Mexican women, those with higher European ancestry have increased risk of breast cancer. We combined an admixture mapping and genome-wide association mapping approach to search for genomic regions that may explain this observation. Latina women with breast cancer (n= 1497) and Latina controls (n= 1272) were genotyped using Affymetrix and Illumina arrays. We inferred locus-specific genetic...

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Identifiers

PMID: 22228098
DOI: 10.1093/hmg/ddr617
PMCID: PMC3313799

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ESR1

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