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Genetic ancestry and risk allele C9orf72 rs3849942 T for amyotrophic lateral sclerosis in Latin American populations.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 May 2025

Flores Sergio V, Lillo Patricia, Levi-Monsalve Alejandro, Roco-Videla Ángel, Montaña Román

Abstract excerpt

This study examines the relationship between genetic ancestry and the rs3849942 T allele, linked to ALS, in 347 Latin American individuals from the 1000 Genomes Project. Ancestry proportions were estimated using 446 AIMs, and associations were analyzed via logistic regression. Higher Native American ancestry significantly reduced the likelihood of carrying the T allele, while European ancestry increased it. These...

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PMID: 40243810
DOI: 10.1080/21678421.2024.2447459

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