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Article

Ancestral Genetic Homogeneity in Preclinical Models May Shape Outcome Differences in Pediatric Brain Cancer.

Cancer research - 14 Aug 2026

Backlund Alexandra, Samaniego Catherine H, Rangaraj Rashika, Campbell Cindy, Cocito Carolina, Souweidane Mark M, Dahmane Nadia, Greenfield Jeffrey P

Abstract excerpt

The influence of genetic ancestry on cancer development and treatment response is underappreciated within pediatric neuro-oncology. Pediatric brain tumors (PBT) comprise the deadliest malignancies among childhood cancers. Poorer prognoses are accentuated in minority populations and remain skewed despite attempts to address social determinants of health and clinical trial underrepresentation. Ancestral differences...

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PMID: 42171642
DOI: 10.1158/0008-5472.CAN-25-5402

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