Article
Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.
Scientific reports - 13 Aug 2020
Romero-Hidalgo Sandra, Flores-Rivera José, Rivas-Alonso Verónica, Barquera Rodrigo, Villarreal-Molina María Teresa, Antuna-Puente Bárbara, Macias-Kauffer Luis Rodrigo, Villalobos-Comparán Marisela, Ortiz-Maldonado Jair, Yu Neng, Lebedeva Tatiana V, Alosco Sharon M, García-Rodríguez Juan Daniel, González-Torres Carolina, Rosas-Madrigal Sandra, Ordoñez Graciela, Guerrero-Camacho Jorge Luis, Treviño-Frenk Irene, Escamilla-Tilch Monica, García-Lechuga Maricela, Tovar-Méndez Víctor Hugo, Pacheco-Ubaldo Hanna, Acuña-Alonzo Victor, Bortolini Maria-Cátira, Gallo Carla, Bedoya Gabriel, Rothhammer Francisco, González-Jose Rolando, Ruiz-Linares Andrés, Canizales-Quinteros Samuel, Yunis Edmond, Granados Julio, Corona Teresa
Abstract excerpt
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican...
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