Article
The impact of Indigenous American-like ancestry on the risk of acute lymphoblastic leukemia in Hispanic/Latino children.
HGG advances - 15 Jan 2026
Langie Jalen, Chan Tsz Fung, Yang Wenjian, Kang Alice Y, Morimoto Libby, Stram Daniel O, Mancuso Nicholas, Ma Xiaomei, Metayer Catherine, Lupo Philip J, Rabin Karen R, Scheurer Michael E, Wiemels Joseph L, Yang Jun J, de Smith Adam J, Chiang Charleston W K
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with Hispanic/Latino children having a higher incidence of ALL than other racial/ethnic groups. Among the genetic variants previously implicated in ALL risk, a number of them were found to be enriched in Indigenous American (IA)-like ancestries and inherited by many Hispanic/Latino individuals. However, due to potential confounding from...
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