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Article

Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS.

The Journal of pathology - 1 Dec 2022

Rifai Olivia M, Longden James, O'Shaughnessy Judi, Sewell Michael DE, Pate Judith, McDade Karina, Daniels Michael Jd, Abrahams Sharon, Chandran Siddharthan, McColl Barry W, Sibley Christopher R, Gregory Jenna M

Abstract excerpt

Clinical heterogeneity observed across patients with amyotrophic lateral sclerosis (ALS) is a known complicating factor in identifying potential therapeutics, even within cohorts with the same mutation, such as C9orf72 hexanucleotide repeat expansions (HREs). Thus, further understanding of pathways underlying this heterogeneity is essential for appropriate ALS trial stratification and the meaningful assessment of...

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Identifiers

PMID: 36070099
DOI: 10.1002/path.6008
PMCID: PMC9827842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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