Article

Machine learning evaluation of gene expression-based ALS subtypes across brain and blood tissues

2026-06-21

Abstract excerpt

The clinical and molecular heterogeneity observed in amyotrophic lateral sclerosis (ALS) presents a challenge for diagnosis, prognosis, and treatment. RNA sequencing of post-mortem brain samples from ALS patients has identified several subtypes with distinct molecular signatures. We sought to evaluate these subtypes across diverse tissues and datasets and assess the feasibility of supervised machine learning model...

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Literature Corpus work: de7ca673-292e-5b59-b5a7-eb93fab93741
DOI: 10.64898/2026.06.19.733362

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