Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.

doi:10.1136/jnnp-2022-330866

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Article

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2023

Asken Breton M, Ljubenkov Peter A, Staffaroni Adam M, Casaletto Kaitlin B, Vandevrede Lawren, Cobigo Yann, Rojas-Rodriguez Julio C, Rankin Katherine P, Kornak John, Heuer Hilary, Shigenaga Judy, Appleby Brian S, Bozoki Andrea C, Domoto-Reilly Kimiko, Ghoshal Nupur, Huey Edward, Litvan Irene, Masdeu Joseph C, Mendez Mario F, Pascual Belen, Pressman Peter, Tartaglia Maria Carmela, Kremers Walter, Forsberg Leah K, Boeve Brad F, Boxer Adam L, Rosen Howie J, Kramer Joel H

Abstract excerpt

BACKGROUND: Measuring systemic inflammatory markers may improve clinical prognosis and help identify targetable pathways for treatment in patients with autosomal dominant forms of frontotemporal lobar degeneration (FTLD). METHODS: We measured plasma concentrations of IL-6, TNFα and YKL-40 in pathogenic variant carriers (MAPT, C9orf72, GRN) and non-carrier family members enrolled in the ARTFL-LEFFTDS Longitudinal...

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Identifiers

PMID: 36977552
DOI: 10.1136/jnnp-2022-330866
PMCID: PMC10313977

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