Article
HHEX promotes myeloid transformation in cooperation with mutant ASXL1.
Blood - 1 Oct 2020
Takeda Reina, Asada Shuhei, Park Sung-Joon, Yokoyama Akihiko, Becker Hans Jiro, Kanai Akinori, Visconte Valeria, Hershberger Courtney, Hayashi Yasutaka, Yonezawa Taishi, Tamura Moe, Fukushima Tsuyoshi, Tanaka Yosuke, Fukuyama Tomofusa, Matsumoto Akiko, Yamasaki Satoshi, Nakai Kenta, Yamazaki Satoshi, Inaba Toshiya, Shibata Tatsuhiro, Inoue Daichi, Honda Hiroaki, Goyama Susumu, Maciejewski Jaroslaw P, Kitamura Toshio
Abstract excerpt
Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional knockin (ASXL1-MT-KI) mice suggested that ASXL1-MT alone is insufficient for myeloid transformation. In our previous study, we used retrovirus-mediated insertional mutagenesis, which exhibited the susceptibility of ASXL1-MT-KI hematopoietic cells to transform into...
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