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Article

Expression of IL-37 Induces a Regulatory T-Cell-like Phenotype and Function in Jurkat Cells.

Cells - 18 Aug 2022

Osborne Douglas Grant, Domenico Joanne, Fujita Mayumi

Abstract excerpt

The anti-inflammatory cytokine interleukin-37 (IL-37) plays a key role in inhibiting innate and adaptive immunity. Past results have shown that IL-37 is elevated in human Treg cells compared to other T cell subsets and contributes to enhancing the Treg transcription factor, forkhead box protein P3 (FOXP3). However, it is unknown if ectopic expression of IL-37 in non-Treg CD4+ T cells can lead to the development...

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Identifiers

PMID: 36010641
DOI: 10.3390/cells11162565
PMCID: PMC9406943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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