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Interleukin-35 Enhances Regulatory T Cell Function by Potentially Suppressing Their Transdifferentiation into a T Helper 17-Like Phenotype in Kawasaki Disease.

Immunological investigations - 1 Nov 2023

Li Hua, Xing Haijian

Abstract excerpt

Interleukin-35 (IL-35) modulates immune cell activity in inflammation and autoimmune disorders. However, its specific effects on regulatory T cells (Tregs) in Kawasaki disease remain ambiguous. We enrolled 37 patients with Kawasaki disease and 20 healthy controls in this study. The percentages of CD4+CD25+CD127dim/- Tregs and CD4+IL-17A+ T helper 17 (Th17) cells were determined via flow cytometry. Tregs were...

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PMID: 37052682
DOI: 10.1080/08820139.2023.2201283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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