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Article

Expression of IL-37 contributes to the immunosuppressive property of human CD4+CD25+ regulatory T cells.

Scientific reports - 28 Sept 2015

Shuai Xu, Wei-min Li, Tong Ya-lin, Dong Ning, Sheng Zhi-yong, Yao Yong-ming

Abstract excerpt

Interleukin-37 (IL-37) possesses the function of down-regulate systemic and local inflammation. It is unknown whether IL-37 is expressed in human regulatory T cells (Tregs) and its role in modulating the immune response of Tregs. In the present study, cell surface molecules and secretory cytokines were analyzed in order to determine the function of IL-37 in regulating inhibitory effect of human...

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Identifiers

PMID: 26411375
DOI: 10.1038/srep14478
PMCID: PMC4585986

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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